"I'd honestly given up. Three years of eating less and nothing moving. Within six weeks on this I'd started feeling warm again for the first time in I don't know how long."
— David K., 52
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If you don't notice a meaningful difference, email us for a full refund. No questions asked.
Metabolism Support Formula
Formulated by Dr Miriam Mikicki MD & Elwin Robinson
Support Healthy Thyroid Function & Metabolic Rate
A targeted 8-ingredient formula for the Low Metabolism Type — formulated to support healthy thyroid function, cellular energy metabolism, and the nutrient cofactors that govern how efficiently your body burns energy at rest.
- 3,5 Diiodo-L-Thyronine (T2) (50mcg) — a naturally occurring thyroid metabolite that research suggests may support healthy thyroid signaling and cellular energy metabolism.†
- Fucoxanthin from Kelp Extract (4mg, standardized to 10% fucoxanthin) — a marine carotenoid studied for its role in supporting healthy metabolic rate and cellular energy use.†
- Thyroid Glandular Powder (100mg, bovine) — a traditional whole-glandular preparation providing the natural cofactors that support thyroid gland function.†
- Plus 5 more research-backed cofactors at clinically relevant doses — L-Carnitine, Iodine, Selenium, Coleus forskohlii, and Yohimbe Extract — detailed below.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
It's Not a Lack of Discipline or Willpower — It's Your Metabolism
7:14 AM. The bathroom scale reads the same number it read last Monday. And the Monday before.
You've eaten less. You've been moving more. You've been careful in every way the advice tells you to be. And the number sits there, stubborn, unchanged — like it's mocking you.
It's 68 degrees in your kitchen and you're layered up again. Jumper, wool socks, hands wrapped around a mug to warm them. You can't remember the last time you felt properly warm from the inside.
Here's the thing — that's not a discipline problem. If you've taken the Hormetics assessment and been identified as the Low Metabolism Type, it suggests your metabolic rate may have slowed below where it should be. The engine that burns what you eat has quietly turned down. And when the engine is running quiet, eating less doesn't help — your body just burns less, too. It adapts. It conserves. It waits.
The Metabolism Support Formula was developed with this pattern in mind. Rather than forcing your metabolism with aggressive stimulants or slashing calories further, it's formulated to support the underlying thyroid signaling and cellular energy pathways that govern how efficiently your body burns energy at rest. Eight ingredients, each selected for the research behind it, at doses that reflect what the research has actually studied.
Haven't taken the Hormetics assessment yet? Take the free quiz here to identify your type before purchasing.
Metabolic rate isn't willpower. It's hormonal signaling — largely driven by the thyroid axis and the cellular machinery that responds to it. The patients I see with slowed metabolism are usually frustrated because they're doing everything they've been told to do and the needle isn't moving. We formulated this blend to support healthy thyroid function, cellular energy metabolism, and the nutrient cofactors that keep those systems running — because when you support the engine rather than just cutting the fuel, many people find their energy and body composition start to shift in a more natural direction.
Dr Miriam Mikicki, MD, Co-Creator of The Hormetics Formulas
UK-trained GP, IFM Certified Practitioner, and pioneer of functional medicine in the UK. Founder of Mikicki Medical and co-founder of Health Miro, a longevity clinic in London. Specializes in root-cause approaches to hormonal balance, thyroid health, and gut health.
Why I Developed This Formula
Let me tell you about David — a composite drawn from the many clients I've worked with who share this exact pattern. What David goes through is what I see again and again with the Low Metabolism Type, and it's part of what convinced me this approach actually works.
David came to me frustrated. He's someone who'd always been able to stay in shape without thinking too hard about it — and then somewhere in his late forties, things changed. He'd been eating less and training harder than he had in years, and his weight hadn't shifted in three years. Not up, not down. Just stuck.
He was also cold all the time. His hands, his feet. He'd layer up indoors, even in summer. His energy never recovered properly — not a crash type of tired, more a constant low-grade drained feeling that coffee didn't touch.
His GP had tested his thyroid and told him the numbers were “in range” — the standard TSH screening came back fine, and he was essentially told to keep doing what he was doing. But keeping doing what he was doing wasn't working, and he knew it.
When we ran a fuller thyroid panel — free T3, free T4, reverse T3, and the key nutrient cofactors the thyroid needs to function — the picture was very different. His conversion from T4 to active T3 was sluggish. His reverse T3 was elevated. Several of the trace minerals the thyroid needs to work properly were on the low end of normal. The engine was real, but it had quietly turned down.
He didn't want to go on thyroid medication if there was another path first. So we worked through the approach the Metabolism Support Formula is built around — the trace minerals the thyroid needs, a unique thyroid hormone metabolite called T2 that research suggests may support thyroid signaling, a marine compound called fucoxanthin that's been studied for metabolic rate, and a traditional glandular preparation — combined with some strength training, sleep, and stress work.
Within about six weeks the cold was gone. His energy came back — not a caffeinated energy, but a genuine background warmth. The scale started moving for the first time in years. He described it as “my body finally working with me instead of against me.”
Now, I know what you might be thinking — you've tried metabolism supplements before and nothing shifted. I get it. The difference with this formula is that every ingredient was chosen based on published research at doses that match what was actually studied — not token amounts for label decoration. These aren't magic. But when the formulation respects the engine rather than trying to whip it, many people experience something genuinely different.
Individual experiences may vary. This is a personal account and is not intended as a guarantee of results.
Calories: The Input vs Metabolism: The Engine
This is something that took me a while to really understand, and once you see it, it changes how you think about weight completely. Your body uses more than one signal to manage how much energy you actually burn. They sound connected, but they work on different levels — and that difference matters.
Calories
The Input
Your calorie intake is the input — what you put into your body through food. It's the number most weight-loss advice is built around: eat less than you burn, and the weight comes off.
Mathematically, it seems clean. Cut 500 calories a day, lose a pound a week.
But that math ignores what's actually happening inside your body when you eat less for weeks or months on end. It assumes the engine that burns fuel keeps running at the same speed regardless of what you do.
It doesn't.
Metabolism
The Engine
Your metabolism is the engine — the cellular and hormonal machinery that actually burns the fuel you put in. Thyroid hormones, mitochondrial function, sympathetic nervous system activity, hundreds of enzymatic reactions working together.
And critically, the engine is not fixed.
When you eat consistently less, your body downregulates thyroid signaling, slows cellular energy production, and conserves. The engine quiets. Research shows total daily energy expenditure can drop by hundreds of calories in response to sustained restriction — far more than simple arithmetic predicts.
This is why cutting calories stops working. Not because you lack discipline. Because your body, trying to protect you, has turned the engine down.
You can restrict your way to a brief weight loss. But you can't restrict your way to a healthy metabolism.
Here's why this matters for the Low Metabolism Type. If you scored highest in the metabolism-related patterns on the Hormetics assessment, it suggests your engine may be running quieter than it should. The good news is metabolism is a signal your body can adjust — with the right thyroid-supporting nutrients and lifestyle strategies, many people find their energy lifts, their warmth returns, and their relationship with weight shifts in ways that calorie counting alone never delivered.
That's why we formulated the Metabolism Support Formula specifically around ingredients with research behind them for supporting healthy thyroid function and cellular energy metabolism. When the engine is better supported as part of an overall healthy lifestyle, many people find their body starts working with them again.†
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What's Inside — And Why Each Ingredient Was Chosen
Every ingredient backed by published clinical research. Doses that reflect what was actually studied — not token amounts for label decoration.
3,5 Diiodo-L-Thyronine (T2)
50mcgNaturally occurring thyroid metabolite
The Thyroid Metabolite With a Metabolic Story
T2 is a naturally occurring metabolite produced when the body processes thyroid hormones. Unlike the more familiar T3 and T4, T2 has been the subject of a growing body of research — published in journals including the FASEB Journal and Frontiers in Physiology — suggesting it may act on cellular energy metabolism through mechanisms distinct from traditional thyroid pathways. We include it at a conservative 50mcg, a dose consistent with supplemental research protocols. It's the formula's most novel ingredient and reflects our preference for research-forward metabolic support over the standard stimulant-heavy approach that dominates this category.†
Fucoxanthin (from Kelp Extract)
4mgMarine carotenoid — standardized to 10% from Laminaria japonica
The Marine Compound Studied for Metabolic Rate
Fucoxanthin is a carotenoid pigment found in brown seaweed. Research published in Diabetes, Obesity and Metabolism and Molecular Medicine Reports has investigated fucoxanthin's effects on metabolic rate and body composition — with findings suggesting it may support healthy thermogenesis and fat metabolism through mechanisms that target cellular energy expenditure rather than stimulant pathways. We include it at 4mg per serving, standardized to 10% from Laminaria japonica kelp, delivering an active dose that matches the range used in clinical research — not a token amount for label decoration.†
Thyroid Glandular Powder
100mgTraditional whole-glandular preparation (bovine)
Traditional Nutrient Support for the Thyroid
Whole-glandular preparations have been used in traditional nutritional practice for over a century. Bovine thyroid powder provides the full spectrum of nutrient cofactors naturally present in healthy thyroid tissue, along with the trace proteins and peptides that support glandular function. Unlike pharmaceutical thyroid preparations, this is not a substitute for thyroid medication — it's nutritional support for the thyroid gland itself. We include 100mg per serving, a supportive dose consistent with traditional glandular nutrition protocols and positioned alongside the iodine and selenium cofactors the thyroid needs to produce its own hormones.†
Not a substitute for thyroid medication. Consult your doctor if you have thyroid disease. See Important Safety Information below.
L-Carnitine (as L-Carnitine L-Tartrate)
500mgAmino acid compound
The Shuttle That Moves Fat Into the Mitochondria
L-Carnitine plays a specific role in cellular energy metabolism: it shuttles long-chain fatty acids into the mitochondria, where they can be used as fuel. Research published in Nutrition & Metabolism and the Journal of the International Society of Sports Nutrition has examined L-Carnitine's role in supporting healthy fat metabolism and cellular energy production. We include 500mg per serving in the well-absorbed L-Carnitine L-Tartrate form — a dose consistent with published research, and one that pairs naturally with the fucoxanthin and thyroid-cofactor ingredients for a layered metabolic support profile.†
Iodine (from Potassium Iodide)
100mcg (67% DV)Essential trace mineral
The Mineral the Thyroid Cannot Function Without
Iodine is the raw material the thyroid gland uses to produce thyroid hormones. Without adequate iodine, healthy thyroid hormone synthesis isn't possible. While severe iodine deficiency is rare in developed countries, research suggests marginal iodine status is more common than generally recognized — particularly among people who avoid iodized salt, dairy, or seafood. Our dose of 100mcg supplies a supportive baseline without approaching upper tolerance levels — which matters because both too little and too much iodine can stress the thyroid. This is considered nutritional support, not therapeutic supplementation.†
Selenium (as Selenium Glycinate)
100mcg (182% DV)Essential trace mineral
The Cofactor That Activates Thyroid Hormone
Selenium is essential for the enzymes that convert T4 (the storage form of thyroid hormone) into T3 (the active form). Research published in the European Journal of Endocrinology and Thyroid has shown that adequate selenium status supports healthy thyroid hormone conversion and metabolic function. We use the chelated selenium glycinate form for superior absorption and gentleness on the stomach. At 100mcg per serving (182% DV), it's a supportive dose that works alongside iodine to ensure the thyroid has the cofactors it needs to function properly.†
Coleus forskohlii Extract
50mgColeus forskohlii (root extract)
A Botanical With Research on Cellular Messengers
Coleus forskohlii is a botanical used in traditional Ayurvedic practice. Modern research, including studies published in Obesity Research and the Journal of the International Society of Sports Nutrition, has investigated its active compound forskolin for effects on cellular signaling pathways involved in energy metabolism and body composition. It's a supporting ingredient in this formula, working alongside the thyroid-focused core rather than leading. We include it at 50mg per serving — a conservative dose that contributes to the overall metabolic support profile without driving the formula's character.†
Yohimbe Extract
1mgPausinystalia yohimbe (bark) — standardized to 2% yohimbine
A Conservative Dose of a Traditional Stimulant
Yohimbe bark extract has a long history of use as a natural stimulant. Research suggests yohimbine — its active compound — may influence sympathetic nervous system activity and support cellular fat metabolism. We include it at a deliberately conservative 1mg per serving: enough to contribute a subtle supportive effect, well below doses associated with stimulant side effects. Our philosophy on Yohimbe is different from most metabolism formulas: instead of using it as the formula's driver (often at 3–5mg+), we use it as a minor supporting ingredient. This is the formula's only significant-risk ingredient — the safety details matter.†
Contains a stimulant. Do not use if you have high blood pressure, anxiety, cardiovascular conditions, or take MAOIs/SSRIs. See Important Safety Information below.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All cited research refers to individual ingredients, not to this specific product formulation.
Why Quality and Transparency Matter
cGMP Certified Manufacturing
The Metabolism Support Formula is manufactured in a facility that follows current Good Manufacturing Practices (cGMP) as established by the FDA. Every batch is produced under strict quality controls — from raw ingredient verification to final product testing — to help ensure consistency, purity, and potency.
Made in the USA
The Metabolism Support Formula is manufactured in the United States in a registered and inspected facility. From ingredient sourcing to final encapsulation, the production process meets US manufacturing standards.
Third-Party Tested
Every batch of the Metabolism Support Formula is independently tested by a third-party laboratory to verify ingredient identity, potency, and purity. This testing is conducted by an accredited laboratory separate from the manufacturing facility, providing an additional layer of quality assurance.
Active IRB-Approved Clinical Study
Key ingredients in the Metabolism Support Formula are currently being evaluated in an active clinical study that has received Institutional Review Board (IRB) approval. IRB approval means the study design, protocols, and participant protections have been reviewed and approved by an independent ethics committee — the same standard of oversight applied to pharmaceutical research.
Physician Developed
The Metabolism Support Formula was co-developed by Dr Miriam Mikicki MD, a qualified medical doctor and functional medicine practitioner, and Elwin Robinson, a health researcher specialising in hormonal and metabolic optimisation. The formula was designed based on published clinical research and real-world clinical experience with hormonal patterns.
Simple to Use, Every Day
Take 2 Capsules Daily
Take two capsules daily with 6–8oz of water, ideally with a meal. No complicated protocols, no specific timing tricks.
Support Your Thyroid Metabolic Engine
The eight targeted ingredients are formulated to support your body's natural thyroid signaling, metabolic energy production, and the essential cofactor systems required.
Give It Time to Work for You
Many people report noticing a shift within the first few weeks — warmth returning, energy steadying. We suggest allowing up to 90 days of consistent use to properly evaluate how it feels for you.†
Join 2,500+ people who've discovered their hormonal archetype
What Changes When Insulin Starts Working For You?
Individual experiences shared with permission. Results vary by type, adherence, and individual factors. These are not typical results and your experience may differ.
The 3pm crash is gone
“Every afternoon, same thing. Energy drops off a cliff. Reach for a biscuit. Feel better for 20 minutes. Crash again. Repeat. I thought that was just how bodies worked after 40. Turns out it was a blood sugar rollercoaster I was putting myself on every single day. Six weeks in and I haven't hit a wall past 3pm once.”
— Michael R., 47
Cravings that finally quieted down
“I've had a sugar problem my entire adult life. Not a sweet tooth — an actual compulsion. I'd eat dinner and then spend the whole evening thinking about dessert. The cravings have genuinely quieted down. I can walk past the biscuit tin now and just... keep walking. That hasn't been true for me in twenty years.”
— Karen B., 52
Something shifted around week four
“I was skeptical. I'd tried so many things. Berberine on its own hadn't done much for me years ago. But something about this formula clicked. My GP noticed the improvement at my next check-up and asked what I'd changed. I told him I'd cleaned up my eating timing and started this. That's it.”
— Sarah M., 43
Not a diet — something better
“I want to be clear — this isn't a diet. Nobody told me to cut calories or count macros. They told me to change the order I eat things and support my body with the right nutrients. That's it. Within two months my energy was completely different — steady all day, no crashes, no cravings.”
— Diane R., 46
Slow start, but it clicked
“Honestly, the first two weeks I wasn't sure. I kept waiting for some dramatic moment and it didn't come. But around week three I noticed I wasn't finishing my lunch and crashing an hour later. I'd say if you're skeptical, give it the full 90 days before you judge it. It's not overnight, but it's real.”
— Robert P., 54
Best £37 I've ever spent
“My doctor told me to lose weight and come back in six months. No guidance on how. This guide gave me the actual mechanism and a protocol. Between the protocol and the formula, I finally understand what's been happening in my body. Wish I'd known this twenty years ago.”
— Lisa T., 51
The "Warmth" Guarantee
Try the formula for 180 days.
If you don't notice a meaningful change in how steady your energy feels… if the cold hands and feet don't ease… if your relationship with your weight hasn't shifted at all… simply email us for a full refund. You keep the bottles.
We back this with a full 180-Day Money-Back Guarantee because we believe in this formula and want you to have time to see how it feels for you.
No questions. No hoops. No forms.
Just email support@hormetics.health and we'll take care of it for you.
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Frequently Asked Questions
THE HORMETICS SYSTEM IS CO-DEVELOPED BY:
Dr. Miriam Mikicki, MD
Medical Doctor and IFM Practitioner
Dr. Miriam Mikicki is a UK-trained GP and IFM Certified Practitioner, and a member of the Institute for Functional Medicine's Certification Board. A pioneer of functional medicine in the United Kingdom, she is founder of Mikicki Medical and co-founder of Health Miro, a longevity and preventative medicine clinic in London. Her specialty is root-cause approaches to hormonal balance, thyroid and autoimmune conditions, gut health and longevity. Her clinical insight — shaped by years of treating patients who were doing everything right but still couldn't reach their health goals — is the foundation of the Hormetics typing system.
Elwin Robinson
Author, Health Researcher, Genetic Expert
Elwin Robinson spent a decade teaching natural health through his online courses and YouTube channel — until a personal health crisis in his late thirties led him to advanced genetic testing, which revealed a root cause no standard test had caught. That experience shaped his guiding principle: if you aren't getting better, it's because nobody has looked in the right place yet. He founded Advanced Health Genetics, has worked with thousands of clients on hormonal and metabolic patterns, and is Author of the Rejuvenate Blueprint Book Series, the Creator of the Hormetics typing system, and host of the Rejuvenate Podcast.
You've identified your type. You know what's been quietly turning down the engine.
Now Give Your Metabolism the Support It Actually Needs
You know what's been driving the cold, the fatigue, the stuck scale. You understand why eating less made it worse. The Metabolism Support Formula was built for exactly this pattern — eight research-backed ingredients, formulated by Dr Miriam Mikicki MD and Elwin Robinson, backed by a 180-day Warmth Guarantee. If it doesn't change how you feel, you pay nothing.
Metabolism Support Formula
From $39/bottle
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Important Safety Information
Please read before ordering. This formula includes thyroid cofactors and a small dose of Yohimbe — both require specific precautions.
Metabolism Support Formula is designed for healthy adults supporting their body's natural metabolic and thyroid function. Because the formula includes ingredients that support thyroid hormone production (iodine, selenium, thyroid glandular) and a conservative dose of Yohimbe (a botanical stimulant), it has specific contraindications you should review before ordering.
Yohimbe — Blood Pressure, Heart & Mental Health
Yohimbe is a stimulant. Even at our conservative 1mg dose, it can influence sympathetic nervous system activity. Do not use this formula if you have:
- High blood pressure or cardiovascular conditions
- Anxiety disorders or panic disorder
- Are taking MAOIs, SSRIs, or other mood medications
- Are sensitive to stimulants (including caffeine intolerance)
Thyroid Medication & Thyroid Disease
If you have a diagnosed thyroid condition (hypothyroidism, hyperthyroidism, Hashimoto's, Graves' disease) or take thyroid medication (Levothyroxine, Synthroid, liothyronine, or any other), do not start this formula without consulting your doctor. The thyroid-supportive ingredients (iodine, selenium, thyroid glandular, T2) can interact with medication and affect hormone levels. Thyroid support is not a substitute for prescribed thyroid medication.
Heart Conditions & Blood Pressure Medication
In addition to the Yohimbe warning above, if you take blood pressure medication or have any cardiovascular condition, speak with your doctor before starting this formula.
Pregnancy, Nursing & Under 18
Metabolism Support Formula is not suitable for use during pregnancy, while breastfeeding, or for individuals under 18. Yohimbe and the thyroid-active ingredients are contraindicated in pregnancy.
Competitive Athletes
Yohimbine is on the prohibited list for some sporting bodies. If you compete in tested sport, verify with your governing body before using this formula.
General
Always consult your healthcare provider before starting any new supplement, particularly if you have a medical condition or are taking prescription medication. Discontinue use and consult your doctor if you experience any adverse effects including elevated heart rate, blood pressure changes, anxiety, or sleep disruption.
Safety Notice
Metabolism Support Formula is not suitable during pregnancy or while nursing, or for individuals under 18. Consult your doctor before use if you have any medical condition, are taking thyroid medication (including levothyroxine, Synthroid, NDT, or similar), are sensitive to stimulants, have high blood pressure or cardiovascular conditions, or are taking MAOIs, SSRIs, or other mood medications. Currently available for shipping within the United States only.
References available upon request. All cited studies refer to individual ingredients, not to this specific product formulation.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This product is a dietary supplement and is not intended to replace professional medical advice. Always consult your healthcare provider before beginning any new supplement regimen. The Hormetics system is designed to support lifestyle optimization and is educational in nature.
© 2026 Hormetics. All rights reserved. Distributed by Lion Heart Solutions, LLC.
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