"Two weeks in and the bloating that had been my normal for five years was just... gone. I kept waiting for it to come back. It hasn't."
— Charlotte W., 34
180-Day Balance Guarantee
If you don't notice a meaningful difference, email us for a full refund. No questions asked.
Estrogen Balance Formula
Formulated by Dr Miriam Mikicki MD & Elwin Robinson
Support Healthy Estrogen Metabolism & Hormonal Balance
A targeted 8-ingredient formula for the High Estrogen Type — formulated to support your body's natural estrogen metabolism through liver phase II detoxification, gut clearance, and the nutrient cofactors involved in healthy hormonal signaling.
- DIM (Diindolylmethane) (100mg) — a compound derived from cruciferous vegetables, studied for its role in <strong>supporting healthy estrogen metabolism</strong> through liver phase I pathways.†
- Calcium D-Glucarate (500mg) — a botanical-derived compound studied for its role in supporting healthy beta-glucuronidase activity and the gut-level clearance of processed estrogen.†
- TUDCA (Tauroursodeoxycholic Acid) (250mg) — a bile acid that research suggests may support healthy liver function and bile flow — both essential to clearing processed hormones from the body.†
- Plus 5 more research-backed cofactors at clinically relevant doses — Vitex (Chaste Berry), Taurine, Zinc, Vitamin B6, and Vitamin D3 — detailed below.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
It's Not a Lack of Discipline or Willpower — It's Your Estrogen
3:00 PM. The bloating starts again. Same time, every day. You've barely eaten anything that should cause it.
By evening, your jeans don't fit the way they did this morning. Your mood has shifted in a way you can't quite explain. The week before your period, this all gets worse — and you've stopped trying to predict which days will be the bad ones, because they're all bad ones now.
Here's the thing — that's not a discipline problem. If you've taken the Hormetics assessment and been identified as the High Estrogen Type, it suggests your body's estrogen clearance pathways may not be working as efficiently as they should. Your liver processes estrogen. Your gut helps eliminate it. And your environment — plastics, toiletries, cleaning products — adds synthetic estrogens to the load. When the clearance side can't keep up with the load side, the symptoms follow.
This isn't a hormonal mystery. It's a pattern with a name and a mechanism — and once you understand it, the symptoms make sense.
The Estrogen Balance Formula was developed with this pattern in mind. Rather than trying to suppress symptoms, it's formulated to support the underlying estrogen metabolism pathways your body uses naturally — liver detoxification, gut clearance, and the nutrient cofactors involved in healthy hormonal signaling. Eight ingredients, each selected for the research behind it, at doses that reflect what the research has actually studied.
Haven't taken the Hormetics assessment yet? Take the free quiz here to identify your type before purchasing.
In my practice, the women I see with this pattern are usually doing everything they've been told to do — eating well, exercising, managing stress — and the symptoms persist anyway. It's because the issue isn't the symptoms. It's that the body's estrogen clearance pathways are overwhelmed. We formulated this blend to support healthy estrogen metabolism, liver detoxification, and the nutrient cofactors involved in healthy hormonal signaling — because when you support the pathways rather than chasing the symptoms, many women find that the bloating, the mood shifts, and the cyclical patterns start to ease in a more natural way.
Dr Miriam Mikicki, MD, Co-Creator of The Hormetics Formulas
UK-trained GP, IFM Certified Practitioner, and pioneer of functional medicine in the UK. Founder of Mikicki Medical and co-founder of Health Miro, a longevity clinic in London. Specializes in root-cause approaches to hormonal balance, thyroid health, and gut health.
Why I Developed This Formula
Let me tell you about Charlotte — a composite drawn from the many women I've worked with who share this exact pattern. What Charlotte goes through is what I see again and again with the High Estrogen Type, and it's part of what convinced me this approach actually works.
Charlotte came to us frustrated. She'd been doing all the right things — eating cruciferous vegetables, cutting back on alcohol, managing her stress, sleeping well. But the bloating had become daily, the week before her period was almost unbearable, and she'd developed a kind of constant low-grade unease about her own body that hadn't been there in her twenties.
Her GP had run hormone tests. The numbers came back “in range.” She was told everything looked normal and to come back if it got worse. But the issue, as she'd already begun to suspect, wasn't that any single hormone reading was abnormal. It was that the ratio between her estrogen and progesterone was off, and her body was struggling to clear estrogen efficiently.
When we looked at the bigger picture — her liver function markers, her gut health, the synthetic estrogens she was being exposed to in her home and personal care products without realising — the story made much more sense. The clearance pathways were overwhelmed. The load was higher than her body could comfortably process. The symptoms followed.
She didn't want to go on the pill or HRT if there was another path. So we worked through the approach the Estrogen Balance Formula is built around — DIM to support liver phase I metabolism, Calcium D-Glucarate to support healthy gut clearance, TUDCA to support bile flow, Vitex as a traditional botanical for hormonal support, and the trace nutrient cofactors the body needs for healthy hormonal signaling — combined with auditing the synthetic estrogens in her environment and supporting her gut.
Within a few cycles, the daily bloating had eased significantly. The premenstrual week wasn't dominating her life the way it had been. She described it as “feeling like myself again, in a way I'd actually started to think wasn't possible anymore.”
Now, I know what you might be thinking — you've tried supplements before, maybe even DIM on its own, and nothing shifted. I get it. The difference with this formula is that every ingredient was chosen based on published research at doses that match what was actually studied — and the formulation works on multiple pathways simultaneously rather than just hammering one. These aren't magic. But when the formulation respects the system rather than fighting it, many women experience something genuinely different.
Individual experiences may vary. This is a personal account and is not intended as a guarantee of results. This product is not intended to diagnose, treat, cure, or prevent any disease.
Symptoms: The Signal vs Estrogen: The Clearance
This is something that took me a while to really understand, and once you see it, it changes how you think about hormonal symptoms completely. Your body is sending you signals — but the signals and the cause are not the same thing. Treating the signal doesn't fix what's sending it.
Symptoms
The Signal
The bloating. The mood shifts. The week before your period that's started to dominate the rest of the month. The unexplained weight that won't shift no matter what you do.
These are signals. Real, frustrating, exhausting signals.
Most approaches focus here. The pill suppresses the cycle. Diuretics suppress the bloating. Antidepressants suppress the mood shifts. Restriction tries to suppress the weight.
But suppression isn't the same as resolution. Turn down the volume on the signal and the underlying cause is still there, still sending it, still building.
Estrogen
The Clearance
Your body produces estrogen naturally — but it also has to clear it. Your liver processes it through Phase I and Phase II detoxification pathways. Your gut eliminates the processed hormones through stool. And your environment adds synthetic estrogens — from plastics, personal care products, and household chemicals — that your body has to process the same way.
When the clearance side can't keep up with the load side, estrogen recirculates. The ratio shifts. The signals start.
Supporting healthy clearance is fundamentally different from suppressing the signal. You're not turning down the volume — you're addressing what's sending it.
Research suggests that supporting Phase I and Phase II liver detoxification, healthy bile flow, gut motility, and the nutrient cofactors involved in healthy hormonal signaling — as part of an overall healthy lifestyle — can help the body do what it was designed to do.
Here's why this matters for the High Estrogen Type. If you scored highest in the estrogen-related patterns on the Hormetics assessment, it suggests your clearance pathways may be carrying more load than they can comfortably process. The good news is these are pathways your body can be supported in. With the right nutrient support and lifestyle strategies, many people find their symptoms ease in a way that suppression alone never delivered.
That's why we formulated the Estrogen Balance Formula specifically around ingredients with research behind them for supporting healthy estrogen metabolism, liver detoxification, and gut clearance. When the clearance pathways are better supported as part of an overall healthy lifestyle, many people find their body starts working with them again.†
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What's Inside — And Why Each Ingredient Was Chosen
Every ingredient backed by published clinical research. Doses that reflect what was actually studied — not token amounts for label decoration.
DIM (Diindolylmethane)
100mgCompound from cruciferous vegetables
The Cruciferous Compound for Estrogen Metabolism
DIM is a compound your body produces when you digest cruciferous vegetables like broccoli, kale, and Brussels sprouts. Research published in journals including Nutrition and Cancer and the Journal of Nutrition has investigated DIM's role in supporting healthy estrogen metabolism — specifically, the ratio between different estrogen metabolites produced through liver Phase I detoxification. We include it at 100mg per serving, a dose consistent with the range used in published research, and positioned as a central ingredient in the formula's estrogen-clearance profile.†
Calcium D-Glucarate
500mgBotanical-derived compound (calcium salt of D-glucaric acid)
The Compound That Supports Gut-Level Estrogen Clearance
Calcium D-Glucarate is a compound naturally found in fruits and vegetables like oranges, apples, and cruciferous vegetables. In the body, it's converted to D-glucaro-1,4-lactone — a compound research has investigated for its role in inhibiting beta-glucuronidase, an enzyme produced by certain gut bacteria. This matters because beta-glucuronidase can reactivate processed estrogen in the gut, sending it back into circulation rather than allowing it to be eliminated. Research published in Cancer Epidemiology Biomarkers & Prevention and the Journal of Cellular Biochemistry has examined Calcium D-Glucarate's role in supporting healthy estrogen clearance pathways. We include it at 500mg per serving, consistent with published research.†
TUDCA (Tauroursodeoxycholic Acid)
250mgBile acid
The Bile Acid That Supports Liver and Bile Flow
TUDCA is a bile acid that occurs naturally in small amounts in the body. Research published in journals including Hepatology and the World Journal of Gastroenterology has investigated TUDCA's role in supporting healthy liver function and bile flow. This matters for estrogen metabolism because bile is the route by which the liver delivers processed hormones to the gut for elimination — when bile flow is sluggish, that elimination can be too. We include it at 250mg per serving, working alongside Calcium D-Glucarate and Taurine to support the bile flow and gut-clearance side of the estrogen metabolism story.†
Vitex (Chaste Berry) Powder
20mgVitex agnus-castus (berry)
A Traditional Botanical for Hormonal Support
Vitex — also known as chaste berry — is a botanical used in traditional herbal practice for centuries, particularly for supporting women's hormonal health. Modern research published in journals including Phytomedicine and Planta Medica has investigated its traditional use in supporting healthy hormonal balance. We include it at a conservative 20mg per serving — a supportive dose that contributes to the formula's overall hormonal support profile without overwhelming the adrenal and liver-focused ingredients that lead the formula. It's the smallest dose on the label by weight, and deliberately so.†
Can interact with hormonal medications (HRT, contraception). Not suitable during pregnancy. See Important Safety Information below.
Taurine
250mgConditionally essential amino acid
The Amino Acid That Supports Bile and Liver Function
Taurine is a sulfur-containing amino acid involved in bile acid conjugation — the process by which the liver prepares hormones and other compounds for elimination. Research published in Amino Acids and the Journal of Biomedical Science has investigated taurine's role in supporting healthy liver function and the bile flow pathway. We include it at 250mg per serving, working synergistically with TUDCA to support the liver-to-gut side of estrogen clearance — the step where processed hormones actually leave the body rather than recirculating.†
Zinc (as Zinc Glycinate)
15mg (136% DV)Essential trace mineral
Essential Cofactor for Hormonal Health
Zinc is involved in hundreds of enzymatic reactions in the body, including many that play a role in healthy hormonal signaling. Research published in journals including Biological Trace Element Research has investigated zinc's role in healthy hormonal balance. We use the chelated zinc glycinate form for superior absorption and gentleness on the stomach — at 15mg per serving (136% DV). It's a baseline mineral that supports the foundational biochemistry behind all the more targeted ingredients in this formula, making sure the cofactors your body needs are actually covered.†
Vitamin B6 (as Pyridoxine HCl)
10mg (588% DV)Essential B-vitamin
The B-Vitamin for Hormonal Pathways
Vitamin B6 is involved in hundreds of biochemical reactions, including the methylation pathways the liver uses to process hormones. Research published in journals including the American Journal of Clinical Nutrition has examined adequate B6 status in the context of hormonal and cardiometabolic health. We include it at 10mg per serving (588% DV) — a supportive dose well within established safe upper levels and directly relevant to the Phase I and Phase II liver detoxification pathways that handle estrogen clearance.†
Vitamin D3 (as Cholecalciferol)
25mcg / 1,000 IU (125% DV)Fat-soluble vitamin/hormone
The Fat-Soluble Vitamin for Hormonal Health
Vitamin D functions more like a hormone than a vitamin — it has receptors in cells throughout the body and is involved in a wide range of physiological processes, including aspects of healthy hormonal signaling. Vitamin D status is often suboptimal in modern populations, particularly during winter months and in northern latitudes. We include it at 25mcg per serving (125% DV) — a supportive maintenance dose, not a therapeutic mega-dose, appropriate for daily use alongside whatever level of sun exposure and dietary intake you're already getting.†
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All cited research refers to individual ingredients, not to this specific product formulation.
Why Quality and Transparency Matter
cGMP Certified Manufacturing
The Estrogen Balance Formula is manufactured in a facility that follows current Good Manufacturing Practices (cGMP) as established by the FDA. Every batch is produced under strict quality controls — from raw ingredient verification to final product testing — to help ensure consistency, purity, and potency.
Made in the USA
The Estrogen Balance Formula is manufactured in the United States in a registered and inspected facility. From ingredient sourcing to final encapsulation, the production process meets US manufacturing standards.
Third-Party Tested
Every batch of the Estrogen Balance Formula is independently tested by a third-party laboratory to verify ingredient identity, potency, and purity. This testing is conducted by an accredited laboratory separate from the manufacturing facility, providing an additional layer of quality assurance.
Active IRB-Approved Clinical Study
Key ingredients in the Estrogen Balance Formula are currently being evaluated in an active clinical study that has received Institutional Review Board (IRB) approval. IRB approval means the study design, protocols, and participant protections have been reviewed and approved by an independent ethics committee — the same standard of oversight applied to pharmaceutical research.
Physician Developed
The Estrogen Balance Formula was co-developed by Dr Miriam Mikicki MD, a qualified medical doctor and functional medicine practitioner, and Elwin Robinson, a health researcher specialising in hormonal and metabolic optimisation. The formula was designed based on published clinical research and real-world clinical experience with hormonal patterns.
Simple to Use, Every Day
Take 2 Capsules Daily
Take two capsules daily with 6–8oz of water, ideally with a meal. No complicated protocols, no specific timing tricks.
Support Your Estrogen Clearance Pathways
The eight targeted ingredients are formulated to support your body's natural estrogen metabolism, liver detoxification, and gut clearance — the pathways your body uses to maintain healthy hormonal balance.
Give It Time to Work for You
Many people report noticing shifts within the first 2–4 weeks. Hormonal patterns build over cycles, so we suggest allowing up to 90 days of consistent use to properly evaluate how it feels for you.†
Join 2,500+ people who've discovered their hormonal archetype
What Happens When Your Estrogen Pathways Start Working For You?
Individual experiences shared with permission. Results vary by type, adherence, and individual factors. These are not typical results and your experience may differ.
Two weeks and the bloating eased
“I'd genuinely accepted that bloating was just my normal. Every evening, my jeans wouldn't fit the way they had that morning. Two weeks in on this and the change was significant. I kept waiting for the bad days to come back. They haven't.”
— Charlotte W., 34
The week before my period feels different
“The week before my period had become the week I just braced for. Mood shifts, exhaustion, the whole thing. Three cycles in on this and that week feels like a normal week now. Not perfect, but not the dread it was.”
— Hannah L., 38
Finally a formula that works on multiple pathways
“I'd tried DIM on its own years ago. Did nothing. What I didn't realise then is that DIM only addresses one part of the puzzle. This formula works on the liver and the gut and the cofactors all at once — and that combination is what made the difference for me.”
— Rebecca T., 42
Subtle but real
“I want to be honest — there was no dramatic moment. No before and after. But around six weeks in I realised I'd stopped tracking my symptoms in my notes app because there was less to track. That's a quieter kind of success but a real one.”
— Sophia M., 36
My skin cleared up too
“I bought this for the bloating, which did improve. But the surprise was my skin. The hormonal acne along my jaw that had been there since my late twenties had quietly faded by the third month. Wasn't expecting that.”
— Olivia P., 31
I feel like myself
“I'd been telling friends I didn't feel like myself anymore. Couldn't pin down exactly why — just a sense of being out of sync with my own body. Two months in I caught myself thinking 'oh, this is what normal feels like.' I'd forgotten.”
— Eleanor K., 45
The "Balance" Guarantee
Try the formula for 180 days.
If you don't notice a meaningful change in how steady your energy feels… if the bloating doesn't ease… if your relationship with your cycle hasn't shifted at all… simply email us for a full refund. You keep the bottles.
We back this with a full 180-Day Money-Back Guarantee because we believe in this formula and want you to have time to see how it feels for you — across multiple cycles.
No questions. No hoops. No forms.
Just email support@hormetics.health and we'll take care of it for you.
Choose Your Package &
Start Supporting Your Estrogen Balance Today
Starter
1 Bottle
30-Day Supply
$59
per bottle
Free USA Shipping
$14.95 International
180-Day Balance Guarantee
3 Bottles
90-Day Supply — Recommended
$49
per bottle
$177$147 total — Save $30
Free USA Shipping
$19.95 International
180-Day Balance Guarantee
Best Value
6 Bottles
180-Day Supply
$39
per bottle
$354$234 total — Save $120
Free USA Shipping
$19.95 International
180-Day Balance Guarantee
Frequently Asked Questions
THE HORMETICS SYSTEM IS CO-DEVELOPED BY:
Dr. Miriam Mikicki, MD
Medical Doctor and IFM Practitioner
Dr. Miriam Mikicki is a UK-trained GP and IFM Certified Practitioner, and a member of the Institute for Functional Medicine's Certification Board. A pioneer of functional medicine in the United Kingdom, she is founder of Mikicki Medical and co-founder of Health Miro, a longevity and preventative medicine clinic in London. Her specialty is root-cause approaches to hormonal balance, thyroid and autoimmune conditions, gut health and longevity. Her clinical insight — shaped by years of treating patients who were doing everything right but still couldn't reach their health goals — is the foundation of the Hormetics typing system.
Elwin Robinson
Author, Health Researcher, Genetic Expert
Elwin Robinson spent a decade teaching natural health through his online courses and YouTube channel — until a personal health crisis in his late thirties led him to advanced genetic testing, which revealed a root cause no standard test had caught. That experience shaped his guiding principle: if you aren't getting better, it's because nobody has looked in the right place yet. He founded Advanced Health Genetics, has worked with thousands of clients on hormonal and metabolic patterns, and is Author of the Rejuvenate Blueprint Book Series, the Creator of the Hormetics typing system, and host of the Rejuvenate Podcast.
You've identified your type. You know what's been driving the bloating, the cyclical patterns, the body that doesn't feel like yours.
Now Give Your Estrogen Pathways the Support They Actually Need
You know what's been driving the daily symptoms. You understand why suppressing them never solved them. The Estrogen Balance Formula was built for exactly this pattern — eight research-backed ingredients, formulated by Dr Miriam Mikicki MD and Elwin Robinson, backed by a 180-day Balance Guarantee. If it doesn't change how you feel, you pay nothing.
Estrogen Balance Formula
From $39/bottle
180-Day Balance Guarantee
Secure checkout via Shopify. 180-day Balance Guarantee. Free USA shipping on all orders.
Know someone who's been struggling too?
Share the free quiz with them — it's free and takes 3 minutes.
The quiz is free. It takes 3 minutes. It might change everything for them.
Important Safety Information
Please read before ordering. This formula is hormonally active and has specific contraindications.
Estrogen Balance Formula is designed for healthy adults supporting their body's natural estrogen metabolism. Because the formula contains Vitex (a botanical with a long history of use for women's hormonal support) alongside ingredients that support liver phase II detoxification and gut-level estrogen clearance, it has specific contraindications you should review before ordering.
Vitex & Hormonal Medication (HRT, Contraception, Fertility)
Vitex can interact with hormonal contraception (the pill, hormonal IUD, implant), HRT, fertility medications, and dopamine-affecting medications. If you take any of these, speak with your doctor before starting this formula. Your doctor should oversee any addition of hormone-supporting supplements.
Hormone-Sensitive Conditions & Cancer History
If you have a current or past history of hormone-sensitive cancer (including breast, ovarian, or endometrial), or are currently taking tamoxifen, aromatase inhibitors, or any other hormone-modulating medication for cancer support, do not use this formula without explicit clearance from your oncologist. Any addition to your hormone-supporting regimen should be made in coordination with your cancer care team.
Pregnancy & Nursing
Estrogen Balance Formula is not suitable for use during pregnancy or while breastfeeding. Vitex specifically is contraindicated in pregnancy. If you become pregnant while taking this formula, discontinue use and speak with your healthcare provider.
Under 18
Not suitable for individuals under 18.
General
Always consult your healthcare provider before starting any new supplement, particularly if you have a medical condition or are taking prescription medication. This formula is designed to support natural estrogen metabolism pathways — it is not intended to start, stop, or alter the menstrual cycle, and significant changes in your cycle should prompt a conversation with your doctor.
Safety Notice
Estrogen Balance Formula is not suitable for use during pregnancy, while breastfeeding, or for individuals under 18. Do not use without consulting your doctor if you are taking hormonal contraception (the pill, hormonal IUD, implant), HRT, fertility medications, or any other hormone-affecting medication. Do not use if you have a current or past history of hormone-sensitive cancer (including breast, ovarian, or endometrial), or are taking tamoxifen, aromatase inhibitors, or other hormone-modulating cancer medications, without explicit clearance from your oncologist. Vitex (one of the ingredients) can interact with hormonal medications and dopamine-affecting medications. Always speak with your healthcare provider before starting any new supplement.
References available upon request. All cited studies refer to individual ingredients, not to this specific product formulation.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This product is a dietary supplement and is not intended to replace professional medical advice. Always consult your healthcare provider before beginning any new supplement regimen. The Hormetics system is designed to support lifestyle optimization and is educational in nature.
© 2026 Hormetics. All rights reserved. Distributed by Lion Heart Solutions, LLC.
Estrogen Balance FormulaFrom $39/bottle180-Day Balance GuaranteeWe use cookies to ensure the best experience and for ad performance.